| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Ergotamine | Red: Avoid combination | Do not coadminister: potentially increased levels of ergotamine | Increased risk of ergotamine adverse effects |
Use alternative agents |
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| Ritonavir Ergotamine 1079 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ergotamine | Increased ergotamine effects (eg, ergotism) |
Not studied |
Not studied (may increase ergotamine levels) |
Contraindicated. Use alternative agents. |
|
| Darunavir Ergotamine 937 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ergotamine | Potential for increased risk of ergotamine adverse effects (e.g. peripheral vasospasm, ischemia) |
Contraindicated. Use alternative agents. |
|||
| Atazanavir Ergotamine 822 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ergotamine | Potential for increased ergotamine effects (eg, ergotism) |
Contraindicated. Use alternative agents. |
|||
| Efavirenz Ergotamine 432 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ergotamine | Potentially increased ergotamine effects (eg, ergotism) |
Not studied |
Not studied (may increase ergotamine levels) |
Avoid combination and use alternative agents |
|
| Elvitegravir Ergotamine 189 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ergotamine | Potential for increased ergot effects (e.g. ergot toxicity, peripheral vasospasm, ischemia) |
Contraindicated. Use alternative agents. |
