Generic
Warfarin
Brand Name
Coumadin
Import ID
148
Warfarin
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Warfarin | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of bleeding |
Use with caution. Monitor INR and for warfarin adverse effects (e.g. bleeding) |
|||
| Ritonavir Warfarin 1050 | Yellow: Adjust dosing | Adjust dosing to avoid increased or reduced levels of warfarin | Decreased warfarin effects (eg, decreased INR, increased risk of clotting) |
12.5 mg daily | INR: decreased |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
|
| Darunavir Warfarin 899 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of warfarin | Decreased warfarin effects (e.g. decreased INR, increased risk of clotting) |
Not reported |
10 mg x 1 | S-warfarin Cmax decrease 8%, AUC decrease 21% |
If coadministering, monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
| Nevirapine Warfarin 634 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential decreased warfarin effects (eg, altered INR, increased risk of clotting) |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
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| Etravirine Warfarin 571 | Orange: Minimal data to guide interaction | minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased Warfarin concentration |
If coadministring, monitor INR |
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| Efavirenz Warfarin 501 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased or decreased warfarin effects (altered INR, increased risk of bleeding or clotting) |
Not studied |
Not studied (may increase or decrease warfarin levels) |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
|
| Efavirenz Warfarin 500 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased or decreased warfarin effects (altered INR, increased risk of bleeding or clotting) |
Not studied |
Not studied (may increase or decrease warfarin levels) |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
|
| Efavirenz Warfarin 499 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased or decreased warfarin effects (altered INR, increased risk of bleeding or clotting) |
Not studied |
Not studied (may increase or decrease warfarin levels) |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
|
| Elvitegravir Warfarin 247 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential over or under anticoagulation |
If coadministering monitor INR and adjust warfarin as indicated. Monitor for signs and symptons of bleeding. |
