| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Thioridazine | Yellow: Adjust dosing | Minimal data to guide interaction: risks likely to outweigh benefits | Potential loss of antiviral efficacy |
Consider using alternative antipsychotic |
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| Darunavir Thioridazine 891 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of thioridazine | Potential for increased risk of thioridazine adverse effects |
If coadministering, dose reduction may be necessary |
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| Elvitegravir Thioridazine 175 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of thioridazine | Potential for increased risk of thioridazine adverse effects |
Initiate lowest starting dose or decrease current dose of antipsychotic. Monitor efficacy and adverse effects. |
