| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Lurasidone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of lurasidone adverse effects |
If initiating lurasidone in a person stable on lenacapavir, recommended starting dose is 20 mg daily, not to exceed 80 mg daily. If initiating lenacapavir in a person stable on lurasidone, reduce lurasidone dose by 50% |
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| Darunavir Lurasidone 946 | Red: Avoid combination | Do not coadminister: Potential for increased lurasidone levels | Potential for increased risk of lurasidone adverse effects |
Contraindicated. Use alternative agents. |
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| Atazanavir Lurasidone 826 | Red: Avoid combination | Do not coadminister: Potential for increased levels of lurasidone | Potential increased in pimozide adverse effects (eg, hypotension, cardiac arrhythmias) |
Contraindicated. Use alternative agents. |
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| Elvitegravir Lurasidone 203 | Red: Avoid combination | Do not coadminister: potential toxicity | Potential serious or life-threatening reactions |
Contraindicated. Use alternative agents. |
