DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of lurasidone adverse effects
Management
If initiating lurasidone in a person stable on lenacapavir, recommended starting dose is 20 mg daily, not to exceed 80 mg daily. If initiating lenacapavir in a person stable on lurasidone, reduce lurasidone dose by 50%
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