| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Cariprazine 873 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of cariprazine | Potential for increased risk of cariprazine adverse effects |
If starting cariprazine in a patient on a protease inhibitor, administer cariprazine 1.5 mg on Day 1 and Day 3, with no dose given on Day 2. From Day 4 onward, administer cariprazine 1.5 mg daily. Dose may be increased to a maximum of cariprazine 3 mg daily. If starting a protease inhibitor for a patient already taking cariprazine 3-6mg, reduce dose by half. For patients taking cariprazine 4.5 mg daily, reduced cariprazine dose to 1.5 - 3 mg daily. For patients taking cariprazine 1.5 mg daily, reduce to cariprazine 1.5 mg every other day. If PI is withdrawn, cariprazine dose may need to be increased. |
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| Nevirapine Cariprazine 627 | Red: Avoid combination | Do not coadminister: potientially reduced levels of cariprazine | Potential decreased cariprazine effects |
Contraindicated. Use alternative agents. |
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| Etravirine Cariprazine 548 | Red: Avoid combination | Do not coadminister: potientially reduced levels of cariprazine | Potential decreased cariprazine effects |
Contraindicated. Use alternative agents. |
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| Efavirenz Cariprazine 444 | Red: Avoid combination | Do not coadminister: Reduced levels of cariprazine | Decreased cariprazine levels |
Avoid combination and use alternative agents |
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| Elvitegravir Cariprazine 158 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of cariprazine | Potential for increased risk of cariprazine adverse effects |
If patient is receiving EVG / c, administer cariprazine 1.5 mg on Day 1 and Day 3, with no dose given on Day 2. From Day 4 onward, administer cariprazine 1.5 mg daily. Dose can be increased to a maximum dose of 3 mg daily. If EVG / c is withdrawn, cariprazine dose may need to be increased. If patient is receiving cariprazine 3 mg or 6 mg daily, reduce cariprazine dose by half. For patients taking cariprazine 4.5 mg daily, the dose should be reduced to 1.5 mg or 3 mg daily. For patients taking cariprazine 1.5 mg daily, change to 1.5 mg every other day. If EVG / c is withdrawn, cariprazine dose may need to be increased. |
