Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of cariprazine
Drug 1
Drug 2
Clinical Effects
Potential for increased risk of cariprazine adverse effects
Management
If patient is receiving EVG / c, administer cariprazine 1.5 mg on Day 1 and Day 3, with no dose given on Day 2. From Day 4 onward, administer cariprazine 1.5 mg daily. Dose can be increased to a maximum dose of 3 mg daily. If EVG / c is withdrawn, cariprazine dose may need to be increased. If patient is receiving cariprazine 3 mg or 6 mg daily, reduce cariprazine dose by half. For patients taking cariprazine 4.5 mg daily, the dose should be reduced to 1.5 mg or 3 mg daily. For patients taking cariprazine 1.5 mg daily, change to 1.5 mg every other day. If EVG / c is withdrawn, cariprazine dose may need to be increased.
Import ID
158
