Generic
Prednisolone
Brand Name
Millipred
Import ID
72
Prednisolone
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Prednisolone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of corticosteroid adverse effects (e.g. Cushing's syndrome and adrenal supression). |
If co-administering, initiate with the lowest starting dose and titrate to clinical effect. Monitor for corticosteroid-related adverse effects (e.g. Cushing's syndrome, adrenal insufficiency). |
|||
| Ritonavir Prednisolone 1054 | Green: Administer standard doses | Administer standard doses | Potential increased prednisolone effects (adrenal insufficiency, Cushing's syndrome). |
20 mg x 1 dose | Prednisolone AUC increased 30%; clearance: decreased 23% |
Do not coadminister unless potential benefits of prednisone outweigh the risks of systemic corticosteroid adverse effects. |
|
| Efavirenz Prednisolone 411 | Green: Administer standard doses | Administer standard doses | Potential for increased prednisolone effects (adrenal insufficiency, Cushing?s syndrome). |
20 mg x 1 | Prednisolone AUC decreased 21% |
||
| Elvitegravir Prednisolone 240 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of adrenal insufficiency and Cushing's syndrome, but PK / PD less affected by strong CYP3A4 inhibitors |
If coadministering for systemic use, monitor for adrenal insufficiency and Cushing's syndrome. Do not coadminister if prednisolone needed for local injections. |
