Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
200 mg BID for 4 and 14 days
Drug 2
Drug 2 dose
20 mg x 1 dose
Drug 2 effect
Prednisolone AUC increased 30%; clearance: decreased 23%
Clinical Effects
Potential increased prednisolone effects (adrenal insufficiency, Cushing's syndrome).
Management
Do not coadminister unless potential benefits of prednisone outweigh the risks of systemic corticosteroid adverse effects.
Import ID
1054
