| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Fluconazole 1066 | Green: Administer standard doses | Administer standard doses | Cmax increased 14.5%; AUC increased 12%; Cmin increased 14% |
400 mg x 1 day, then 200 mg days 2-5 | |||
| Atazanavir Fluconazole 814 | Green: Administer standard doses | Administer standard doses | No significant change |
200 mg daily x 10 days | No significant change |
||
| Nevirapine Fluconazole 586 | Green: Administer standard doses | Administer standard doses | Potential for increased nevirapine effects |
200 mg three times weekly | Monitor for nevirapine toxicity |
||
| Nevirapine Fluconazole 585 | Green: Administer standard doses | Administer standard doses | Increased nevirapine effects |
200 mg daily x 40 days | No significant change |
Monitor for nevirapine toxicity |
|
| Etravirine Fluconazole 522 | Green: Administer standard doses | Administer standard doses | Increased etravirine effects |
Etravirine AUC increased 86%; Cmax increased 75%; Cmin increased 109% |
200 mg QAM | No significant change |
Monitor for fluconazole associated toxicities |
| Efavirenz Fluconazole 413 | Green: Administer standard doses | Administer standard doses | AUC increased 16%; Cmax no significant change |
200 mg x 7 days | No significant change |
