Paroxetine
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Paroxetine 897 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of paroxetine | Potential decreased paroxetine effects |
No significant change |
20 mg once daily | Cmax decrease 36%, AUC decrease 39%, Cmin decrease 37% |
Titrate paroxetine to effect; monitor for continued antidepressant response if darunavir / ritonavir initiated |
| Etravirine Paroxetine 531 | Green: Administer standard doses | Administer standard doses | No significant change |
20 mg daily | No significant change |
||
| Elvitegravir Paroxetine 168 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of paroxetine | Potential for increased risk of paroxetine adverse effects |
If coadministering initiate paroxetine at lowest dose. Monitor response and titrate dose according to efficacy and adverse effects. |

