Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of paroxetine
Drug 1
Drug 1 dose
600 mg with 100 mg ritonavir BID
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
20 mg once daily
Drug 2 effect
Cmax decrease 36%, AUC decrease 39%, Cmin decrease 37%
Clinical Effects
Potential decreased paroxetine effects
Management
Titrate paroxetine to effect; monitor for continued antidepressant response if darunavir / ritonavir initiated
Import ID
897
