Generic
Desipramine
Brand Name
Norpramin
Import ID
42
Desipramine
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Desipramine 1056 | Green: Administer standard doses | Administer standard doses | Increased desipramine effects (eg, dry mouth, dizziness, urinary retention) |
Not studied |
Desipramine clearance: decreased 59% |
Monitor and adjust desipramine as indicated |
|
| Darunavir Desipramine 1007 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of desipramine adverse effects (e.g. nausea, dizziness, hypotension, syncope) |
If coadministering, initiate desipramine at low dose. Monitor for CNS and cardiovascular effects. |
|||
| Elvitegravir Desipramine 125 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of desipramine | Increased desipramine effects |
Not reported |
50 mg single dose | Cmax increased 24%, AUC increased 65% |
If coadministering, initiate low dose desipramine and titrate according to efficacy and adverse effects. |
