| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Nevirapine Bupropion 587 | Green: Administer standard doses | Administer standard doses | Decreased bupropion effects |
Monitor for signs and symptoms of depression and titrate bupropion to effect |
|||
| Efavirenz Bupropion 400 | Green: Administer standard doses | Administer standard doses | Decreased bupropion effects |
150 mg SR x 1 | Bupropion AUC decreased 55%; Cmax decreased 34%; half-life: decreased 46% |
Monitor for signs and symptoms of depression and titrate bupropion to effect |
|
| Efavirenz Bupropion 399 | Green: Administer standard doses | Administer standard doses | Decreased bupropion effects |
150 mg SR x 1 | Bupropion AUC decreased 55%; Cmax decreased 34%; half-life: decreased 46% |
Monitor for signs and symptoms of depression and titrate bupropion to effect |
|
| Efavirenz Bupropion 398 | Green: Administer standard doses | Administer standard doses | Decreased bupropion effects |
150 mg SR x 1 | Bupropion AUC decreased 55%; Cmax decreased 34% |
Monitor for signs and symptoms of depression and titrate bupropion to effect |
|
| Elvitegravir Bupropion 155 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of bupropion | Potential for increased risk of bupropion adverse effects |
If coadministering initiate bupropion at lowest dose. Monitor response and titrate according to efficacy and adverse effects. |
