| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Lamotrigine 868 | Yellow: Adjust dosing | Adjust dosing to avoid decreased levels of lamotrigine | Potential for decreased anticonvulsant effects |
Monitor anticonvulsant level and adjust accordingly |
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| Atazanavir Lamotrigine 800 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of lamotrigine | Atazanavir with ritonavir may decrease lamotrigine plasma concentrations, Atazanavir without ritonavir is most likely not clinically significant |
No significant change |
100 mg daily | AUC decreased 32% |
No dose adjustment necessary if administering lamotrigine and atazanavir alone. If administering lamotrigine and atazanavir plus ritonovir, lamotrigine maintenance dose may need to be increased. |
| Raltegravir Lamotrigine 301 | Green: Administer standard doses | Administer standard doses | 100 mg | No significant change |
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| Elvitegravir Lamotrigine 178 | Green: Administer standard doses | Administer standard doses | Potential for increased anticonvulsant effects |
Frequent clinical monitoring is recommended |
