Reyataz label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of lamotrigine
Drug 1
Drug 1 dose
Atazanavir 400mg daily or Atazanavir 300 mg with Ritonavir 100 mg daily
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
100 mg daily
Drug 2 effect
AUC decreased 32%
Clinical Effects
Atazanavir with ritonavir may decrease lamotrigine plasma concentrations, Atazanavir without ritonavir is most likely not clinically significant
Management
No dose adjustment necessary if administering lamotrigine and atazanavir alone. If administering lamotrigine and atazanavir plus ritonovir, lamotrigine maintenance dose may need to be increased.
Import ID
800
