| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Fentanyl | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased risk of fentanyl adverse effects |
If coadministering, monitor therapeutic effects and adverse reactions (e.g. sedation, respiratory depression) |
|||
| Ritonavir Fentanyl 1041 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of fentanyl | Increased fentanyl effects (eg, increased sedation, confusion, respiratory depression) |
5 mcg / kg | Fentanyl clearance decreased 67% |
Monitor closely, start with low dose and titrate to pain response as indicated |
|
| Darunavir Fentanyl 975 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of fentanyl adverse effects (e.g. respiratory depression) |
Clinical monitoring is recommended |
|||
| Elvitegravir Fentanyl 274 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of sedation and respiratory depression |
If coadministering, titrate carefully and monitor for sedation and respiratory depression |
