Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of fentanyl
Drug 1
Drug 1 dose
Day 1: 200 mg TID; Day 2: 300 mg TID; Day 3: 300 mg QAM
Drug 2
Drug 2 dose
5 mcg / kg
Drug 2 effect
Fentanyl clearance decreased 67%
Clinical Effects
Increased fentanyl effects (eg, increased sedation, confusion, respiratory depression)
Management
Monitor closely, start with low dose and titrate to pain response as indicated
Import ID
1041
