Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
500 mg BID x 10 days
Drug 2
Drug 2 dose
50 mg PO x 1 dose
Drug 2 effect
Meperidine AUC decreased 67%; normeperidine AUC increased 47%
Clinical Effects
Increased normeperidine effects
Management
If coadministering monitor for pain control and adjust dose as indicated
Alternative Agents
Morphine
Import ID
1100
