Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid decreased levels of olanzapine
Drug 1
Drug 1 dose
500 mg BID
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
10 mg daily
Drug 2 effect
Olanzapine AUC decreased 53%; half-life: decreased 50%; clearance: increased 115%; Cmax decreased 40%
Clinical Effects
Decreased olanzapine effects
Management
Monitor clinical improvement and adjust olanzapine as indicated
Import ID
1035
