| Boosted |
|---|
|
No
|
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Rilpivirine (IM) Metformin | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Digoxin | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Tenofovir disoproxil fumarate | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Raltegravir | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Darunavir/ritonavir | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Acetaminophen | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Erythromycin | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased rilpivirine concentrations |
Consider alternative agents. If coadministration is necessary, monitor for adverse effects |
|||
| Rilpivirine (IM) Clarithromycin | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased rilpivirine concentrations |
Consider alternative agents. If coadministration is necessary, monitor for adverse effects |
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| Rilpivirine (IM) Azithromycin | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased rilpivirine concentrations |
Consider alternative agents. If coadministration is necessary, monitor for adverse effects |
|||
| Rilpivirine (IM) Dexamethasone | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects if dexamethasone is given as more than a single-dose treatment |
Use alternative agents if therapy requires more than a single dose treatment of dexamethasone. |
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| Rilpivirine (IM) Phenytoin | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
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| Rilpivirine (IM) Phenobarbital | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
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| Rilpivirine (IM) RFB | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
|||
| Rilpivirine (IM) RIF | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
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| Rilpivirine (IM) Omeprazole | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) RPT | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
|||
| Rilpivirine (IM) St. John's Wort (Hypericum perforatum) | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
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| Rilpivirine (IM) Oxcarbazepine | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
|||
| Rilpivirine (IM) CBZ | Red: Avoid combination | Do not coadminister: Potential for reduced levels of rilpivirine | Decreased rilpivirine effects |
Use alternative agents |
|||
| Rilpivirine (IM) SOF/VEL | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Famotidine | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) SOF | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Chlorzoxazone | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Sildenafil | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Ethinyl estradiol / Norethindrone acetate | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) DTG | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Atorvastatin | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Ketoconazole | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased rilpivirine concentrations |
If coadministering, use standard doses and consider monitoring for antifungal efficacy and QTc prolongation |
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| Rilpivirine (IM) Aluminum and magnesium hydroxide antacid | Green: Administer standard doses | Administer standard doses | |||||
| Rilpivirine (IM) Methadone | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for reduced methadone concentrations |
If coadministering, monitor for methadone efficacy |
