| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Zolpidem | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of excessive sedation |
If coadministering, initiate lowest starting dose. Monitor for excessive sedation. |
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| Ritonavir Zolpidem 1058 | Green: Administer standard doses | Administer standard doses | Increased zolpidem effects (eg, increased sedation, confusion) |
5 mg x 1 dose | Zolpidem AUC increased 28%; Cmax increased 22% |
Monitor for excess sedation |
|
| Darunavir Zolpidem 1014 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of zolpidem adverse effects |
If coadministering, initiate zolpidem at low dose and titrate to effect |
|||
| Elvitegravir Zolpidem 253 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of sedative-hypnotic adverse effects |
If coadministering start with low dose and titrate accordingly. Monitor for side effects. |
