| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Buspirone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of buspirone adverse effects |
If coadministering start with lowest dose and titrate to clinical effect. Monitor for buspirone-related adverse events. |
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| Darunavir Buspirone 1006 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of busprione adverse effects |
If coadministering, initiate buspirone at low dose and titrate to effect |
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| Elvitegravir Buspirone 156 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of buspirone | Potential for increased risk of buspirone adverse effects |
If coadministering start with low dose buspirone and titrate accordingly. A dose reduction may be required. Monitor for side effects. |
