| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Calcifediol 872 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of calcifediol | Potential for increased risk of calcifediol adverse effects |
If coadministering, dose adjustment may be required. Monitor serum 25-hydroxyvitamin D, intact PTH, and serum calcium concentrations |
|||
| Elvitegravir Calcifediol 157 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of calcifediol | Monitor serum 25-hydroxyvitamin D, intact PTH, and serum Ca concentrations. Adjust dose as needed. |
