| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Fluvastatin 875 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of fluvastatin | Potential for increased risk of fluvastatin adverse effects |
Consider using alternative agents. If coadministering, initate lowest recommended dose and titrate while monitoring |
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| Efavirenz Fluvastatin 360 | Yellow: Adjust dosing | adjust dosing to avoid increased levels of fluvastatin | Potential for increased levels of fluvastatin |
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| Fostemsavir Fluvastatin 30 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased statin exposure and risk of statin associated adverse events |
If co-adminstering, use lowest possible starting dose and monitor for statin associated adverse events |
