| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Elvitegravir Sucralfate 149 | Yellow: Adjust dosing | Adjust dosing to avoid decreased elvitegravir efficacy | Potential decrease in antiretroviral efficacy |
Separate elvitegravir / cobicistat from sucralfate by at least 2 hours. |
|||
| Dolutegravir Sucralfate 94 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of dolutegravir | Potential decrease in antiretroviral efficacy |
Not studied (may decreased dolutegravir levels) |
Not studied |
Administer dolutegravir 2 hours before or 6 hours after sucralfate |
