Generic
Lansoprazole
Brand Name
Prevacid
Import ID
168
Lansoprazole
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Atazanavir Lansoprazole 785 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of atazanavir | Potential loss of antiretroviral efficacy |
Atazanavir AUC decreased 94%, Cmax decreased 91%, half-life: no significant change |
60 mg daily x 2 doses | Do not coadminister PPIs with unboosted atazanavir. PPIs may be administered 12 hours before atazanavir when boosted with ritonavir or cobicistat, in treatment naive patients. Doses should not exceed the equivalent of omeprazole 20 mg daily. PPIs are not recommended for treatment experienced patients. |
