| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Methylergonovine | Red: Avoid combination | Do not coadminister: potentially increased levels of methylergonovine | Increased risk of methylergonovine adverse effects |
Use alternative agents |
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| Elvitegravir Methylergonovine 192 | Red: Avoid combination | Do not coadminister: Potential for increased levels of methylergonovine | Potential for increased ergot effects (e.g. ergot toxicity, peripheral vasospasm, ischemia) |
Contraindicated. Use alternative agents. |
