| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Dihydroergotamine | Red: Avoid combination | Do not coadminister: potentially increased levels of dihydroergotamine | Increased risk of dihydroergotamine adverse effects |
Use alternative agents |
|||
| Darunavir Dihydroergotamine 926 | Red: Avoid combination | Do not coadminister: Potential for increased dihydroergotamine levels | Potential for increased risk of dihydroergotamine adverse effects (e.g. peripheral vasospasm, ischemia) |
Contraindicated. Use alternative agents. |
|||
| Elvitegravir Dihydroergotamine 188 | Red: Avoid combination | Do not coadminister: Potential for increased levels of dihydroergotamine | Potential for increased ergot effects (e.g. ergot toxicity, peripheral vasospasm, ischemia) |
Contraindicated. Use alternative agents. |
