Vorapaxar
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Vorapaxar 1092 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Not studied |
Not studied (may increase effects of vorapaxar |
Avoid combination and use alternative antiplatelet agent |
|
| Darunavir Vorapaxar 965 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased bleeding risk |
Avoid combination and use alternative antiplatelet agent |
|||
| Atazanavir Vorapaxar 849 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Use alternative agents |
|||
| Elvitegravir Vorapaxar 213 | Red: Avoid combination | Do not coadminister: Potential for increased levels of vorapaxar | Potential for increased risk of bleeding |
Avoid combination and use alternative antiplatelet agent |

