Ticagrelor
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Ticagrelor 1093 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Not studied |
Not studied (may increase ticagrelor levels) |
Avoid combination and use alternative antiplatelet agent |
|
| Darunavir Ticagrelor 964 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased bleeding risk |
Avoid combination and use alternative antiplatelet agent |
|||
| Atazanavir Ticagrelor 848 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Use alternative agents |
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| Nevirapine Ticagrelor 632 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Possible decreased ticagrelor levels |
Avoid combination and use alternative agents |
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| Efavirenz Ticagrelor 484 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Possible decreased ticagrelor levels |
Avoid combination and use alternative agents |
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| Elvitegravir Ticagrelor 212 | Red: Avoid combination | Do not coadminister: Potential for increased levels of ticagrelor | Potential for increased risk of bleeding |
Avoid combination and use alternative antiplatelet agent. |

