Mexiletine
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Mexiletine 947 | Red: Avoid combination | Do not coadminister: Potential for increased mexiletine levels | Potential for increased risk of mexiletine adverse effects |
Use alternative agents |
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| Atazanavir Mexiletine 855 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of mexiletine adverse effects |
If coadministering use with caution and monitor for mexiletine toxicity |
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| Elvitegravir Mexiletine 267 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of mexiletine adverse effects |
If coadministering use with caution and monitor for mexiletine toxicity. Consider therapeutic drug monitoring and ECG |

