Flecainide
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Flecainide 1101 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased flecainide effects (eg, cardiac arrhythmias) |
Not studied |
Not studied (may increase flecainide levels) |
If coadministering use with caution and monitor for toxicity. Consider therapeutic drug monitoring |
|
| Darunavir Flecainide 919 | Red: Avoid combination | Do not coadminister: Increased levels of flecainide | Potential for increased risk of flecainide adverse effects |
Use alternative agents |
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| Atazanavir Flecainide 856 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of flecainide adverse effects (eg, cardiac arrhythmias) |
If coadministering use with caution and monitor for toxicity. Consider therapeutic drug monitoring |
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| Elvitegravir Flecainide 265 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of flecainide adverse effects (eg, cardiac arrhythmias) |
If coadministering use with caution and monitor for flecainide toxicity. Consider therapeutic drug monitoring and ECG |

