Edoxaban
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Edoxaban | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of bleeding |
Use with caution. Monitor for edoxaban adverse effects (e.g. bleeding) |
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| Darunavir Edoxaban 901 | Green: Administer standard doses | Administer standard doses | No dose adjustment if CrCL < 50 ml / min. Avoid concomitant use if CrCl > 50ml / min. |
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| Elvitegravir Edoxaban 164 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of edoxaban | Potential for increased risk of bleeding |
Edoxaban 30 mg once daily if using for DVT / PE. No adjustment needed for stroke prevention in persons with atrial fibrillation. |

