Dofetilide
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Dofetilide 936 | Red: Avoid combination | Do not coadminister: Potential for increased levels of dofetilide | Potential for increased risk of dofetilide adverse effects |
Use alternative agents |
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| Elvitegravir Dofetilide 205 | Red: Avoid combination | Do not coadminister: Potential for increased levels of dofetilide | Potential for increased risk of dofetilide adverse effects |
Use alternative agents |
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| Dolutegravir Dofetilide 115 | Red: Avoid combination | Do not coadminister: Potential for increased levels of dofetilide | Potential for increased dofetilide toxicity |
Not studied |
Not studied |
Contraindicated. Use alternative agents. |
|
| Bictegravir Dofetilide 71 | Red: Avoid combination | Do not coadminister: Potential for increased levels of dofetilide | Potentially increased dofetilide exposure and cardiac arrhythmias |
Contraindicated. Use alternative agents. |

