Disopyramide
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Disopyramide | Red: Avoid combination | Do not coadminister: potentially increased levels of disopyramide | Potential increased risk of disopyramide adverse effects |
Use alternative agents. |
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| Darunavir Disopyramide 935 | Red: Avoid combination | Do not coadminister: Potential for increased levels of disopyramide | Potential for increased risk of disopyramide adverse effects |
Use alternative agents |
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| Atazanavir Disopyramide 854 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of disopyramide adverse effects |
If coadministering use with caution and monitor for disopyramide toxicity |
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| Elvitegravir Disopyramide 264 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of disopyramide adverse effects |
If coadministering use with caution and monitor for disopyramide toxicity. Consider therapeutic drug monitoring and ECG |
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| Bictegravir Disopyramide 85 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increase in disopyramide effects |
If coadministering, monitor for disopyramide adverse effects |

