Clopidogrel
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Clopidogrel | Yellow: Adjust dosing | Minimal data to guide interaction: risks likely to outweigh benefits | Potential increased risk of bleeding |
Consider using alternative ARV or antiplatelet agents. If coadministering, monitor for clopidogrel-related adverse events (e.g. bleeding) |
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| Darunavir Clopidogrel 922 | Red: Avoid combination | Do not coadminister: Potential for decreased clopidogrel levels | Potential for increased bleeding risk |
Use alternative agents |
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| Etravirine Clopidogrel 558 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential decreased clopidogrel effects |
Avoid combination and use alternative agents |
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| Efavirenz Clopidogrel 483 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Possible decreased activation of clopidogrel |
Avoid combination and use alternative agents |
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| Elvitegravir Clopidogrel 214 | Red: Avoid combination | Do not coadminister: Potential for reduced levels of clopidogrel | Potential reduction of antiplatelet activity |
Use alternative agents |

