Amiodarone
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Amiodarone | Red: Avoid combination | Do not coadminister: potentially increased levels of amiodarone | Potential increased risk of amiodarone and lenacapavir adverse effects |
Use alternative agents. |
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| Ritonavir Amiodarone 1077 | Red: Avoid combination | Do not coadminister: Potential for increased levels of amiodarone | Increased amiodarone effects (eg, cardiac arrhythmias) |
Not studied |
Not studied (may increase amiodarone levels) |
Do not coadminister |
|
| Darunavir Amiodarone 984 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of amiodarone adverse effects (e.g. hypotension, bradycardia, cardiac arrhythmias) |
If coadministering use with caution. Monitor for amiodarone toxicity. Consider ECG and amiodarone drug level monitoring. |
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| Atazanavir Amiodarone 858 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased amiodarone effects (eg, hypotension, bradycardia, cardiac arrhythmias) |
If coadministering use with caution. Monitor for amiodarone toxicity. Consider ECG and amiodarone drug level monitoring. |
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| Elvitegravir Amiodarone 263 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased amiodarone effects (eg, hypotension, bradycardia, cardiac arrhythmias) |
If coadministering use with caution and monitor for amiodarone toxicity. Consider therapeutic drug monitoring and ECG. |

