| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Salmeterol 992 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of salmeterol adverse effects |
Use alternative agents |
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| Atazanavir Salmeterol 830 | Red: Avoid combination | Do not coadminister: Potential for increased levels of salmeterol | QT prolongation, palpitations, and sinus tachycardia. |
Contraindicated. Use alternative agents. |
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| Elvitegravir Salmeterol 210 | Red: Avoid combination | Do not coadminister: Potential for increased levels of salmeterol | Increased risk of cardiovascular adverse events (e.g. QT prolongation, palpitations, sinus tachycardia) |
Use alternative agents |
