| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Rilpivirine (IM) SOF | Green: Administer standard doses | Administer standard doses | |||||
| Darunavir SOF 912 | Green: Administer standard doses | Administer standard doses | No significant change |
400 mg x 1 | Cmax increase 45%, AUC increase 34% |
||
| Tenofovir disoproxil fumarate SOF 732 | Green: Administer standard doses | Administer standard doses | Cmax increase 25% |
400 mg x 1 | Cmax decrease 19% |
||
| Rilpivirine SOF 654 | Green: Administer standard doses | Administer standard doses | 400 mg x 1 | Sofosbuvir Cmax increased 21% |
|||
| Efavirenz SOF 427 | Green: Administer standard doses | Administer standard doses | 400 mg x 1 | Sofosbuvir Cmax decreased 19% |
|||
| Raltegravir SOF 313 | Green: Administer standard doses | Administer standard doses | No significant change |
400 mg x 1 | Sofosbuvir Cmax decreased 43%; AUC decreased 27% |
