| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir G/P 931 | Red: Avoid combination | Do not coadminister: Potential for increased glecaprevir / pibrentasvir levels | Potential for increased glecaprevir / pibrentasvir adverse effects |
Use alternative agents |
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| Tenofovir disoproxil fumarate G/P 731 | Green: Administer standard doses | Administer standard doses | (when given with EFV / FTC) |
Not studied (may increase TDF levels) |
Not studied |
||
| Lamivudine G/P 693 | Green: Administer standard doses | Administer standard doses | No significant change |
300 mg / 120 mg daily | GLE AUC decrease 25%, PIB AUC decrease 28% |
||
| Etravirine G/P 546 | Red: Avoid combination | Do not coadminister: Potential for reduced levels of glecaprevir / Pibrentasvir | Potentially decreased glecaprevir / pibrentasvir levels expected |
Not studied (may decrease grazprevir levels) |
Avoid combination. Use alternative agents |
||
| Efavirenz G/P 453 | Red: Avoid combination | Do not coadminister: Reduced levels of Pibrenatasvir / Glecaprevir | decreased pibrenatasvir / glecaprevir effects |
Contraindicated. Use alternative agents. |
|||
| Efavirenz G/P 450 | Red: Avoid combination | Do not coadminister: Reduced levels of glecaprevir / pibrentasvir | Possible decrease in glecaprevir and pribrentasvir levels |
contraindicated. Use alternative agents. |
|||
| Efavirenz G/P 449 | Red: Avoid combination | Do not coadminister: Reduced levels of glecaprevir / pibrentasvir | Possible decrease in glecaprevir and pribrentasvir levels |
contraindicated. Use alternative agents. |
|||
| Raltegravir G/P 311 | Green: Administer standard doses | Administer standard doses | Raltegravir AUC increased 47%; Cmin increased 164% |
300 / 120 mg daily | Not reported |
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| Elvitegravir G/P 181 | Green: Administer standard doses | Administer standard doses | Potential increase in GLEC / PIB toxicity |
AUC increased 47% |
Glecaprevir AUC increased 3 fold; PIB AUC increased 57% |
