| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Tenofovir disoproxil fumarate Adefovir 747 | Red: Avoid combination | Do not coadminister: Potential for increased levels of TDF | Potential for increased risk of TDF adverse effects and / or increased concentration of other renally eliminated drugs |
No significant change |
10 mg once daily | No significant change |
Avoid combination and use alternative agents |
| Tenofovir alafenamide Adefovir 716 | Red: Avoid combination | Do not coadminister: Potential for increased levels of TAF | Potential for increased renal adverse effects |
Not studied |
Not studied |
Contraindicated. Use alternative agents. |
|
| Lamivudine Adefovir 694 | Green: Administer standard doses | Administer standard doses | Not studied |
10 mg daily | No significant change |
