| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Pimozide | Red: Avoid combination | Do not coadminister: potentially increased levels of pimozide | Potential increased risk of pimozide adverse effects |
Contraindicated. Use alternative agents |
|||
| Ritonavir Pimozide 1080 | Red: Avoid combination | Do not coadminister: Potential for increased levels of pimozide | Increased pimozide effects (eg, hypotension, cardiac arrhythmias) |
Not studied |
Not studied (may increase pimozide levels) |
Contraindicated. Use alternative agents. |
|
| Darunavir Pimozide 940 | Red: Avoid combination | Do not coadminister: Potential for increased levels of pimozide | Potential for increased risk of pimozide adverse effects (e.g. hypotension, cardiac arrhythmias) |
Contraindicated. Use alternative agents. |
|||
| Atazanavir Pimozide 827 | Red: Avoid combination | Do not coadminister: Potential for increased levels of pimozide | Potential increased in pimozide adverse effects (eg, hypotension, cardiac arrhythmias) |
Contraindicated. Use alternative agents. |
|||
| Elvitegravir Pimozide 197 | Red: Avoid combination | Do not coadminister: Potential for increased levels of pimozide | Potential serious or life-threatening reactions such as cardiac arrhythmia. |
Contraindicated. Use alternative agents. |
