| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Pimavanserin 893 | Yellow: Adjust dosing | Adjust dosing to avoid increased pimavanserin levels | Potential for increased risk of pimavanserin adverse effects |
If coadministering, decrease dose of pimavanserin to 10 mg once daily |
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| Nevirapine Pimavanserin 626 | Red: Avoid combination | Do not coadminister: Reduced levels of pimavanserin | Decreased pimavanserin levels |
Avoid combination and use alternative agents |
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| Etravirine Pimavanserin 549 | Red: Avoid combination | Do not coadminister: potientially reduced levels of pimavanserin | Potential decreased pimavanserin effects |
Contraindicated. Use alternative agents. |
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| Efavirenz Pimavanserin 454 | Red: Avoid combination | Do not coadminister: Reduced levels of pimavanserin | Decreased pimavanserin levels |
Avoid combination and use alternative agents |
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| Elvitegravir Pimavanserin 170 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of pimavanserin | Potential for increased risk of nefazodone adverse effects |
Reduce pimavanserin dose to 10 mg |
