| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Perphenazine 949 | Red: Avoid combination | Do not coadminister: Potential for increased perphenazine levels | Potential for increased risk of perphenazine adverse effects |
Contraindicated. Use alternative agents. |
|||
| Elvitegravir Perphenazine 169 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of perphenazine | Potential for increased risk of perphenazine adverse effects |
Initiate lowest starting dose or decrease current dose of antipsychotic. Monitor efficacy and adverse effects. |
