| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Lumateperone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of lumateperone adverse effects |
If coadministering, reduce lumateperone dose to 21 mg |
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| Nevirapine Lumateperone 620 | Red: Avoid combination | Do not coadminister: Reduced levels of lumateperon | Decreased Lumateperon levels |
Avoid combination and use alternative agents |
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| Etravirine Lumateperone 547 | Red: Avoid combination | Do not coadminister: Reduced levels of lumateperon | Decreased Lumateperon levels |
Avoid combination and use alternative agents |
|||
| Efavirenz Lumateperone 452 | Red: Avoid combination | Do not coadminister: Reduced levels of lumateperon | Decreased Lumateperon levels |
Avoid combination and use alternative agents |
|||
| Elvitegravir Lumateperone 204 | Red: Avoid combination | Do not coadminister: potential toxicity | Potential for increased risk of lumateperone adverse effects |
Use alternative agents |
