| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Brexpiprazole | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of brexpiprazole adverse effects |
If coadministering in patients known to be poor CYP2D6 metabolizers, use 1/4 of brexpiprazole dose. Monitor for adverse events. |
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| Darunavir Brexpiprazole 879 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of brexpiprazole | Potential for increased risk of brexpiprazole adverse effects |
Administer 25% of the usual brexpiprazole dose. Titrate dose based on clinical monitoring for efficacy / adverse events. |
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| Elvitegravir Brexpiprazole 152 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of aripiprazole | Potential for increased risk of brexpiprazole adverse effects |
Administer 25% of usual bexpiprazole dose and titrate based on efficacy and adverse effects |
