| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Mefloquine | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of mefloquine adverse effects |
If coadministering, monitor for mefloquine adverse effects (e.g. QT prolongation) |
|||
| Ritonavir Mefloquine 1067 | Green: Administer standard doses | Administer standard doses | AUC decreased 31%; Cmax increased 36%; Cmin decreased 43% |
250 mg daily x 3 days, then once weekly for 3 weeks | No significant change |
