Generic
Prednisone
Brand Name
Deltasone
Import ID
73
Prednisone
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Prednisone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of corticosteroid adverse effects (e.g. Cushing's syndrome and adrenal supression). |
If co-administering, initiate with the lowest starting dose and titrate to clinical effect. Monitor for corticosteroid-related adverse effects (e.g. Cushing's syndrome, adrenal insufficiency). |
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| Elvitegravir Prednisone 245 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of adrenal insufficiency and Cushing's syndrome, but PK / PD less affected by strong CYP3A4 inhibitors |
If coadministering monitor for adrenal insufficiency and Cushing's syndrome |
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| Dolutegravir Prednisone 110 | Green: Administer standard doses | Administer standard doses | Cmax increased 6%, AUC increased 11%, Cmin increased 17% |
60 mg daily with taper | Not studied |
