Budesonide
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Budesonide | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of corticosteroid adverse effects (e.g. Cushing's syndrome and adrenal supression). |
If coadministering, initiate lowest starting dose and titrate to clinical effect. Monitor for adverse effects such as adrenal insufficiency and Cushing's syndrome. |
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| Darunavir Budesonide 969 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for decreased plasma cortisol concentrations (e.g. Cushing's syndrome, adrenal suppression) |
Avoid combination or use alternative agents, particularly for long term use |
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| Elvitegravir Budesonide 228 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of adrenal insufficiency and Cushing's syndrome |
Use alternative agents |

